SINCE Wwii, medical science has progressed with a stage where competitive medications are around to treat exactly the same ailment in different people. This is not almost brands (the trade issue) but generic drugs (the scientific issue). In this report, we shall go through the various factors that decide the selection of a specific drug.
Safety: The subsequent sub-criteria must be considered beneath the criterion of safety:
* Acute therapeutic index: If the patient’s condition is acute, how effective is really a particular drug regardless of whether it has certain side-effects so long as the acuteness in the condition is lowered? Example: narcotic pain-killers work well in healing pain but include the possibility side-effect of addiction.
* Long-term safety: medicine may be safe in short-term treatment, so how safe it is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but can have undesirable effects in the event of prolonged use.
* Drug-drug interaction risk: Drugs are chemicals, and a lot of chemicals answer develop a different chemical, which has an effect that will harm the person or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to make a new condition that warrants separate treatment.
Drug-drug interaction risk is of two sorts:
· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, separate from the other, have certain effects on one or higher body processes (e.g., metabolism) that affects the performance in the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) depends upon due to the metabolism. This will cause a rise in the side-effects of Lexapro.
· Pharmacodynamic: Here, several drugs actually create the same relation to exactly the same organ, thus helping the total, added effect. Example: Lexapro has certain side-effects including drowsiness and fatigue. Darvocet-N also acts similarly around the brain. Thus, the side-effects of both drugs are more serious.
Tolerability: A drug may be effective however, not tolerable by all patients. Example: Allergies to specific drugs in most people. Short-term and long-term tolerability must be looked at. Efficacy: A drug is not equally efficient at all patients. For example, some patients with depression or anxiety disorders experience rest from escitalopram, but there are many that do not, who therefore must be prescribed another anti-depressant. The pace of oncoming of therapeutic action is a vital key to be looked at too.
Cost: Cost does not necessarily mean the expense of acquisition of a particular medicine alone. It ought to also cover the expense of treatments for a complication that will arise while using another drug. Example: Inside a person who insists on taking alcohol and yet needs to be treated for depression is normally administered an SSRI drug because they drugs don’t potentiate the end results of alcohol, whereas another number of anti-depressants (including tricyclics) can cause a whole new overuse injury in such patients, which will need a different and expensive treatment. Therefore, it’s safer to prescribe the more expensive escitalopram instead of a cheaper tricyclic in these patients.
Simple treatment: The easiest mode of administration is preferred. If there is a selection between an injection and oral administration, the latter is preferred when the efficacy of both modes is analogous. Or, local application is preferred to the oral route where possible; e.g., antibiotic treatments for eye infections. Dosage and frequency of administration too are key point to decide simple treatment.
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