Search engine for touristic excursions to any place in the world SINCE World War II, medical science has progressed to some stage where competitive medications are around for treat precisely the same ailment in different people. This is not nearly brands (the industry trade issue) but generic drugs (the industry scientific issue). With this report, we shall consider the various factors that decide selecting a certain drug.
Safety: These sub-criteria has to be considered within the criterion of safety:
* Acute therapeutic index: If the patient’s condition is acute, how effective can be a particular drug even if they have certain side-effects as long as the acuteness with the condition is lowered? Example: narcotic pain-killers are amazing in healing pain but feature the possibility side-effect of addiction.
* Long-term safety: drug could be safe in short-term treatment, but exactly how safe it really is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but can have undesirable effects in case of prolonged use.
* Drug-drug interaction risk: Medicine is chemicals, and lots of chemicals react to make a different chemical, that have an effect which could harm the person or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to produce a new condition that warrants separate treatment.
Drug-drug interaction risk is of two sorts:
· Pharmacokinetic: In this type of drug-drug interaction, two drugs, separate from each other, have certain effects one or more body processes (e.g., metabolism) that affects the performance with the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) depends on because of its metabolism. This causes a rise in the side-effects of Lexapro.
· Pharmacodynamic: Here, a couple of drugs actually create the same influence on precisely the same organ, thus helping the total, added effect. Example: Lexapro has certain side-effects for example drowsiness and fatigue. Darvocet-N also acts similarly about the brain. Thus, the side-effects of the two medicine is more intense.
Tolerability: A medication could be effective however, not tolerable by all patients. Example: Allergies to particular drugs in certain people. Short-term and long-term tolerability need to be considered. Efficacy: A medication is not equally good at all patients. As an example, some patients with depression or anxiety attacks experience relief from escitalopram, but there are lots of that do not, who therefore need to be prescribed some other anti-depressant. The speed of oncoming of therapeutic action is an important key to be regarded too.
Cost: Cost does not necessarily mean the expense of acquisition of a particular medicine alone. It ought to also cover the expense of treatment of a complication which could arise while using some other drug. Example: In a one who insists on taking alcohol yet has to be treated for depression is often administered an SSRI drug as these drugs don’t potentiate the effects of alcohol, whereas another band of anti-depressants (for example tricyclics) could cause a fresh problem in such patients, which would demand a different and expensive treatment. Therefore, it’s preferable to prescribe the more costly escitalopram rather than cheaper tricyclic such patients.
Simple treatment: The simplest mode of administration is preferred. If you find an alternative between an injection and oral administration, aforementioned is preferred if the efficacy of the two modes is comparable. Or, local application is chosen over the oral route where possible; e.g., antibiotic treatment of eye infections. Dosage and frequency of administration too are an important factor to choose simplicity of treatment.
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