Nicotine, a compound mostly located in the plants from the Solanaceae family, is an alkaloid and it is found accumulated within the leaves of these plants, the biosynthesis of this chemical occur in the roots from the plants. Nicotine is one of the major components of addictive plants like tobacco (0.6%-3.0%) and it is the reason behind their addiction in humans due to its psychoactive nature.
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1. Etymology
The name nicotine originates from the scientific name from the tobacco plant Nicotiana tabacum. The scientific name from the tobacco plant is itself named in france they ambassador to Portugal Jean Nicot de Villemain. Villeman is credited for sending tobacco seeds and plant saplings to Paris in 1560 for the utilization in medicinal purposes.
2. Extraction
Nicotine was obtained from the tobacco plant by German physician Dr. Wilhelm Heinrich Posselt and chemist Karl Ludwig Reimann in 1828. After its discovery Posselt and Reimann labelled becoming a poison. The truth is nicotine is an antiherbivore chemical, that causes addiction when consumed in control (1mg or fewer) and death if taken in high amounts (30mg-60mg).
3. Chemistry
Nicotine is an alkaloid using the chemical formula C10H14N2. Its IUPAC name is 3[2,5-1-methylpyrrolidin-2-yl]pyridine. It features a molecular mass of 162.12g/mol. Nicotine is a hygroscopic liquid which is miscible with water like a nitrogenous base. Its density is 1.01g/cm3, melting point -79oC and boiling point 247oC. The nicotine molecule includes a half time of Two hours and its particular metabolism is hepatic. Nicotine can be optically active and contains two enantiomeric forms.
4. Nicotine as an insecticide
As already said nicotine is an antiherbivore drug which if taken in a lot is fatal alive forms. That is why nicotine laden tobacco was used as an insecticide could the World War II. But after the WWII its usage drastically lowered as a result of option of cheap synthetic insecticides for the best easily accessible than tobacco and less unhealthy for mammals. But in the recent times the hype surrounding organic farming has again increased the interest from the farmers within the usage of tobacco like a pesticide as an alternate to traps.
5. Nicotine addiction
Our central nervous system has certain nicotinic acetylcholine receptors. Nicotine binds to several of these and enhances the amount of several neurotransmitters. Among these neurotransmitters dopamine is but one such neurotransmitter which is significantly increased during nicotine use and it is to blame for the sense of euphoria and relaxation caused by using tobacco (nicotine) products.
6. Psychoactive outcomes of nicotine
Nicotine is a psychoactive substance because it is mood altering. It causes both euphoria and relaxation. Within the body nicotine is metabolised within the liver. First after its metabolism nicotine ends in the production of glucose through the liver and epinephrine through the adrenal medulla. This sudden relieve glucose and epinephrine causes euphoria after the utilization of nicotine. Following your initial euphoria nicotine leads to relaxation, increased alertness and sharpness by implementing different neurotransmitters from the body. Nicotine boasts pain relieving properties.
7. Unwanted effects of nicotine intake
Tough it looks like nicotine is a wonderful substance to increase one’s sharpness, induce calmness and elevate one’s mood there are other negative aspects of nicotine intake than positive. Among these the most typical side effects of nicotine intake are an increased likelihood of hypertension and cardiac arrest. It can be sad that each cigarette which a man smokes reduces his life span by 14 years. Moreover since nicotine has been seen as to affect the working of Estrogen on hippocampus, hence over time nicotine users are inclined to amnesia and other connected diseases.
8. Toxicity
Nicotine is known as more toxic than most popular drugs like heroin and cocaine. More damage is completed by nicotine to the human body since it is readily absorbed by the bloodstream and reaches the mind through the lungs within 7 seconds of the intake either orally or as the nicotine patch.
9. Using nicotine in medical science
Though nicotine isn’t a doctor’s closest friend, it’s though not his worst foe. Nicotine known for its pain relieving properties has been researched upon to be utilized like a potential prescribed analgesic minus its nasty effects. Nicotine has additionally been found to reduce preeclampsia, allergic asthma; among others by becoming an anti-inflammatory agent.
10. Nicotine in literature
Nicotine continues to be personified in popular literature as Nick O’ Teen, a humanoid villainous character in Superman comics which has been created as an element of anti-nicotine drive to educate children regarding the ill-effects of nicotine intake in any form.
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